jmetal.test.survivalanalysis.GenerateSurvivalGraphOld.java Source code

Java tutorial

Introduction

Here is the source code for jmetal.test.survivalanalysis.GenerateSurvivalGraphOld.java

Source

//GenerateSurvivalCurveData.java
//
//Author:
//   Nasimul Noman <nasimul.noman@newcastle.edu.au>
//
//Copyright (c) 2014 Nasimul Noman
//
//This program is free software: you can redistribute it and/or modify
//it under the terms of the GNU Lesser General Public License as published by
//the Free Software Foundation, either version 3 of the License, or
//(at your option) any later version.
//
//This program is distributed in the hope that it will be useful,
//but WITHOUT ANY WARRANTY; without even the implied warranty of
//MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
//GNU Lesser General Public License for more details.
//
//You should have received a copy of the GNU Lesser General Public License
//along with this program.  If not, see <http://www.gnu.org/licenses/>. * SurvivalAnalysis.java

package jmetal.test.survivalanalysis;

import java.io.File;
import java.util.Enumeration;

import mySurvAnalysis.*;

import org.rosuda.JRI.Rengine;
import org.rosuda.JRI.REXP;

import weka.clusterers.ClusterEvaluation;
import weka.clusterers.HierarchicalClusterer;
import weka.core.Attribute;
import weka.core.EuclideanDistance;
import weka.core.ChebyshevDistance;
import weka.core.Instances;
import weka.core.converters.ArffSaver;
import weka.core.converters.ConverterUtils.DataSource;
import weka.filters.Filter;
import weka.filters.unsupervised.attribute.Remove;
import jmetal.core.Problem;
import jmetal.core.Solution;
import jmetal.encodings.solutionType.BinarySolutionType;
import jmetal.encodings.variable.Binary;

/**
 * Class for generating data for Survival Analysis Curve. 
 * After MOGA selects the feature the selected features are represented by chromosome  
 * This class takes the chromosome as input and then creates separate files for creating survival curves 
 */

public class GenerateSurvivalGraphOld extends Problem {

    private String dataFileName;
    private String testDataFileName;
    private Attribute attTime;
    private Attribute attCensor;
    private Boolean printClusterAssignment = true;
    public Rengine re;

    public int SolutionID = 1;

    /**
     * Creates a new GenerageSurvivalGraph instance
     * @param solutionType Solution type
     * @param numberOfBits Length of the problem
     * @param dataFileName Name of the file containing data
     * @param rEng R Engine
     */
    public GenerateSurvivalGraphOld(String solutionType, Integer numberOfBits, String dataFileName,
            String testDataFile, Rengine rEng) {
        numberOfVariables_ = 1;
        numberOfObjectives_ = 2;
        numberOfConstraints_ = 0;
        problemName_ = "SurvivalAnalysisGraph";
        this.dataFileName = dataFileName;
        this.testDataFileName = testDataFile;
        this.re = rEng;

        solutionType_ = new BinarySolutionType(this);

        length_ = new int[numberOfVariables_];
        length_[0] = numberOfBits;

        if (solutionType.compareTo("Binary") == 0)
            solutionType_ = new BinarySolutionType(this);
        else {
            System.out.println("SurvivalAnalaysis: solution type " + solutionType + " invalid");
            System.exit(-1);
        }
    } // SurvivalAnalysis

    /** 
     * Evaluates a solution - actually generate the survival graph 
     * @param solution The solution to evaluate
     */
    public void evaluate(Solution solution) {
        Binary variable;
        int counterSelectedFeatures;

        DataSource source;

        double testStatistic = Double.MAX_VALUE;
        double pValue = Double.MAX_VALUE;
        //double statScore;
        REXP x;

        variable = ((Binary) solution.getDecisionVariables()[0]);

        counterSelectedFeatures = 0;

        System.out.println("\nSolution ID " + this.SolutionID);

        try {
            // read the data file 
            source = new DataSource(this.dataFileName);
            Instances data = source.getDataSet();
            //System.out.print("Data read successfully. ");
            //System.out.print("Number of attributes: " + data.numAttributes());
            //System.out.println(". Number of instances: " + data.numInstances());

            // save the attribute 'T' and 'Censor'
            attTime = data.attribute(data.numAttributes() - 2);
            attCensor = data.attribute(data.numAttributes() - 1);

            // First filter the attributes based on chromosome
            Instances tmpData = this.filterByChromosome(data, solution);

            // Now filter the attribute 'T' and 'Censor'
            Remove filter = new Remove();
            // remove the two last attributes : 'T' and 'Censor'
            filter.setAttributeIndices("" + (tmpData.numAttributes() - 1) + "," + tmpData.numAttributes());
            //System.out.println("After chromosome filtering no of attributes: " + tmpData.numAttributes());
            filter.setInputFormat(tmpData);
            Instances dataClusterer = Filter.useFilter(tmpData, filter);

            Enumeration<Attribute> attributeList = dataClusterer.enumerateAttributes();
            System.out.println("Selected attributes: ");
            while (attributeList.hasMoreElements()) {
                Attribute att = attributeList.nextElement();
                System.out.print(att.name() + ",");
            }

            System.out.println();
            // filtering complete

            // Debug: write the filtered dataset
            /*
            ArffSaver saver = new ArffSaver();
            saver.setInstances(dataClusterer);
            saver.setFile(new File("filteered-data.arff"));
            saver.writeBatch();
             */

            // train hierarchical clusterer

            HierarchicalClusterer clusterer = new HierarchicalClusterer();
            clusterer.setOptions(new String[] { "-L", "COMPLETE" }); // complete linkage clustering
            //clusterer.setDebug(true);
            clusterer.setNumClusters(2);
            clusterer.setDistanceFunction(new EuclideanDistance());
            //clusterer.setDistanceFunction(new ChebyshevDistance());
            clusterer.setDistanceIsBranchLength(false);

            clusterer.buildClusterer(dataClusterer);

            // Cluster evaluation:
            ClusterEvaluation eval = new ClusterEvaluation();
            eval.setClusterer(clusterer);

            if (this.testDataFileName != null) {

                DataSource testSource = new DataSource(this.testDataFileName);

                Instances tmpTestData = testSource.getDataSet();
                tmpTestData.setClassIndex(tmpTestData.numAttributes() - 1);
                //testSource.

                // First filter the attributes based on chromosome
                Instances testData = this.filterByChromosome(tmpTestData, solution);
                //String[] options = new String[2];
                //options[0] = "-t";
                //options[1] = "/some/where/somefile.arff";
                //eval.
                //System.out.println(eval.evaluateClusterer(testData, options));
                eval.evaluateClusterer(testData);
                System.out.println("\nCluster evluation for this solution: " + eval.clusterResultsToString());
            }

            // Print the cluster assignments:

            // save the cluster assignments
            //if (printClusterAssignment==true){
            int[] clusterAssignment = new int[dataClusterer.numInstances()];
            int classOneCnt = 0;
            int classTwoCnt = 0;
            for (int i = 0; i < dataClusterer.numInstances(); ++i) {
                clusterAssignment[i] = clusterer.clusterInstance(dataClusterer.get(i));
                if (clusterAssignment[i] == 0) {
                    ++classOneCnt;
                } else if (clusterAssignment[i] == 1) {
                    ++classTwoCnt;
                }
                //System.out.println("Instance " + i + ": " + clusterAssignment[i]);
            }

            System.out.println("Class 1 cnt: " + classOneCnt + " Class 2 cnt: " + classTwoCnt);
            //}

            /*
                
                         
                     // create arrays with time (event occurrence time) and censor data for use with jstat LogRankTest
                     double[] time1 = new double[classOneCnt];   
                     double[] censor1 = new double[classOneCnt];
                     double[] time2 = new double[classTwoCnt];
                     double[] censor2 = new double[classTwoCnt];
                
                
                     //data = source.getDataSet();
                     for (int i=0, cnt1=0, cnt2=0; i<dataClusterer.numInstances(); ++i){
                        clusterAssignment[i] = clusterer.clusterInstance(dataClusterer.get(i));
                        if (clusterAssignment[i]==0){
                           time1[cnt1] = data.get(i).value(attTime);
                           censor1[cnt1++] = 1;
                           //System.out.println("i: " + i + " T: " + time1[cnt1-1]);
                        }
                        else if (clusterAssignment[i]==1){
                           time2[cnt2] = data.get(i).value(attTime);
                           //System.out.println("i: " + i + " T: " + time2[cnt2-1]);
                           censor2[cnt2++] = 1;
                        }
                        //System.out.println("Instance " + i + ": " + clusterAssignment[i]);
                     }
                
                
                
                     //Instances[] classInstances = separateClassInstances(clusterAssignment, this.dataFileName,solution);
                     //System.out.println("Class instances seperated");
                
                     // calculate log rank test and p values
                         
                     //LogRankTest testclass1 = new LogRankTest(time1, censor1, time2, censor2);
                     //testStatistic = testclass1.testStatistic;
                     //pValue = testclass1.pValue;
                
                
                     WilcoxonTest testclass1 = new WilcoxonTest(time1, censor1, time2, censor2);
                     testStatistic = testclass1.testStatistic;
                     pValue = testclass1.pValue;true
            */

            String strT = "time1 <- c(";
            String strC = "censor1 <- c(";
            String strG = "group1 <- c(";

            for (int i = 0; i < dataClusterer.numInstances() - 1; ++i) {
                strT = strT + (int) data.get(i).value(attTime) + ",";
                strG = strG + clusterer.clusterInstance(dataClusterer.get(i)) + ",";
                strC = strC + (int) data.get(i).value(attCensor) + ",";

            }

            int tmpi = dataClusterer.numInstances() - 1;
            strT = strT + (int) data.get(tmpi).value(attTime) + ")";
            strG = strG + clusterer.clusterInstance(dataClusterer.get(tmpi)) + ")";
            strC = strC + (int) data.get(tmpi).value(attCensor) + ")";

            this.re.eval(strT);
            this.re.eval(strC);
            this.re.eval(strG);

            // for MyLogRankTest

            double[] time1 = new double[classOneCnt];
            double[] time2 = new double[classTwoCnt];
            double[] censor1 = new double[classOneCnt];
            double[] censor2 = new double[classTwoCnt];

            int i1 = 0, i2 = 0;

            for (int i = 0; i < dataClusterer.numInstances(); ++i) {

                strT = strT + (int) data.get(i).value(attTime) + ",";
                strG = strG + clusterer.clusterInstance(dataClusterer.get(i)) + ",";
                strC = strC + (int) data.get(i).value(attCensor) + ",";

                if (clusterer.clusterInstance(dataClusterer.get(i)) == 0) {
                    time1[i1] = data.get(i).value(attTime);
                    censor1[i1] = data.get(i).value(attCensor);
                    ++i1;
                } else {
                    time2[i2] = data.get(i).value(attTime);
                    censor2[i2] = data.get(i).value(attCensor);
                    ++i2;
                }

            }

            /** If you are calling surv_test from coin library */
            /*v
            re.eval("library(coin)");
            re.eval("grp <- factor (group)");
            re.eval("result <- surv_test(Surv(time,censor)~grp,distribution=\"exact\")");
                
            x=re.eval("statistic(result)");
            testStatistic = x.asDouble();
            //x=re.eval("pvalue(result)");
            //pValue = x.asDouble();
            //System.out.println("StatScore: " + statScore + "pValue: " + pValue);
            */

            /** If you are calling survdiff from survival library (much faster) */
            re.eval("library(survival)");
            re.eval("res21 <- survdiff(Surv(time1,censor1)~group1,rho=0)");
            x = re.eval("res21$chisq");
            testStatistic = x.asDouble();
            //System.out.println(x);
            x = re.eval("pchisq(res21$chisq, df=1, lower.tail = FALSE)");
            //x = re.eval("1.0 - pchisq(res2$chisq, df=1)");
            pValue = x.asDouble();
            System.out.println("Results from R:");
            System.out.println("StatScore: " + testStatistic + "  pValue: " + pValue);

            re.eval("timestrata1.surv <- survfit( Surv(time1, censor1)~ strata(group1), conf.type=\"log-log\")");
            re.eval("timestrata1.surv1 <- survfit( Surv(time1, censor1)~ 1, conf.type=\"none\")");
            String evalStr = "jpeg('SurvivalPlot-" + this.SolutionID + ".jpg')";
            re.eval(evalStr);
            re.eval("plot(timestrata1.surv, col=c(2,3), xlab=\"Time\", ylab=\"Survival Probability\")");
            re.eval("par(new=T)");
            re.eval("plot(timestrata1.surv1,col=1)");
            re.eval("legend(0.2, c(\"Group1\",\"Group2\",\"Whole\"))");
            re.eval("dev.off()");

            System.out.println("Results from my code: ");
            LogRankTest lrt = new LogRankTest(time1, time2, censor1, censor2);
            double[] results = lrt.logRank();
            System.out.println("Statistics: " + results[0] + " variance: " + results[1] + " pValue: " + results[2]);

        } catch (Exception e) {
            // TODO Auto-generated catch block
            System.err.println("Can't open the data file.");
            e.printStackTrace();
            System.exit(1);
        }

        /**********
         *  Current Implementation considers two objectives
         *  1. pvalue to be minimized / statistical score to be maximized
         *  2. Number of Features to be maximized/minimized
         */

    } // evaluate

    /*******************************************************
     * Separates the data file into two based on class assignments of instances 
     * @param classAssignment
     * @param fileName
     * @return
     * @throws Exception
     */

    private Instances[] separateClassInstances(int[] classAssignment, String fileName, Solution solution)
            throws Exception {
        Instances classInstances[] = new Instances[2];
        Instances tmpInstances[] = new Instances[2];
        DataSource source = new DataSource(fileName);

        tmpInstances[0] = source.getDataSet();
        tmpInstances[1] = source.getDataSet();

        // First filter the attributes based on chromosome
        classInstances[0] = filterByChromosome(tmpInstances[0], solution);
        classInstances[1] = filterByChromosome(tmpInstances[1], solution);

        // Now filter instances into two files based on class assignment

        // filter class 1 instances : remains class 0 instances
        for (int i = classAssignment.length - 1; i >= 0; --i) {
            //Instance inst = classInstances[0].get(i);
            if (classAssignment[i] == 0) {
                classInstances[0].delete(i);
            }
        }

        // filter class 0 instances : remains class 1 instances
        for (int i = classAssignment.length - 1; i >= 0; --i) {
            //Instance inst = classInstances[0].get(i);
            if (classAssignment[i] == 1) {
                classInstances[1].delete(i);
            }
        }

        // Save instances

        ArffSaver saver = new ArffSaver();
        saver.setInstances(classInstances[0]);
        saver.setFile(new File("class-0.arff"));
        //saver.setDestination(new File("./data/test.arff"));   // **not** necessary in 3.5.4 and later
        saver.writeBatch();

        saver = new ArffSaver();
        saver.setInstances(classInstances[1]);
        saver.setFile(new File("class-1.arff"));
        //saver.setDestination(new File("./data/test.arff"));   // **not** necessary in 3.5.4 and later
        saver.writeBatch();

        return classInstances;
    }

    /******************************************************
     * Filters the features based on the current chromosome/solution
     *  
     */
    Instances filterByChromosome(Instances data, Solution solution) {

        Binary variable = ((Binary) solution.getDecisionVariables()[0]);
        Instances dataClusterer = null;

        // Use the individual chromosome as the selected features: '1' selected, '0' filtered
        // i.e. Select attributes to be removed based on Individual's chromosome
        Remove filter = new Remove();
        int cntFilteredAttr = 0; // count the number of attributes to be removed
        for (int i = 0; i < variable.getNumberOfBits(); ++i) {
            if (!variable.bits_.get(i)) {
                ++cntFilteredAttr;
            }
        }

        int[] filteredAttributes = new int[cntFilteredAttr];
        for (int i = 0, j = 0; i < variable.getNumberOfBits(); ++i) {
            if (!variable.bits_.get(i)) {
                filteredAttributes[j] = i;
                ++j;
            }
        }

        filter.setAttributeIndicesArray(filteredAttributes);
        try {
            filter.setInputFormat(data);
            dataClusterer = Filter.useFilter(data, filter);
        } catch (Exception e) {
            // TODO Auto-generated catch block
            System.err.print("Problem in filtering attributes according to chromosome");
            e.printStackTrace();
        }

        // filtering complete
        return (dataClusterer);
    }

    public String getDataFileName() {
        return this.dataFileName;
    }

} // GenerateSurvivalCurveData