<Window x:Class="LayoutPanels.DoubleSplitWindow" xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation" xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml" Title="DoubleSplitWindow" Height="300" Width="300" > <Grid> <Grid.ColumnDefinitions> <ColumnDefinition></ColumnDefinition> <ColumnDefinition Width="Auto"></ColumnDefinition> <ColumnDefinition></ColumnDefinition> </Grid.ColumnDefinitions> <Grid Grid.Column="0" VerticalAlignment="Stretch"> <Grid.RowDefinitions> <RowDefinition></RowDefinition> <RowDefinition></RowDefinition> </Grid.RowDefinitions> <Button Margin="3" Grid.Row="0">Top Left</Button> <Button Margin="3" Grid.Row="1">Bottom Left</Button> </Grid> <GridSplitter Grid.Column="1" Width="3" VerticalAlignment="Stretch" HorizontalAlignment="Center" ShowsPreview="False"></GridSplitter> <Grid Grid.Column="2"> <Grid.RowDefinitions> <RowDefinition></RowDefinition> <RowDefinition Height="Auto"></RowDefinition> <RowDefinition></RowDefinition> </Grid.RowDefinitions> <Button Grid.Row="0" Margin="3">Top Right</Button> <Button Grid.Row="2" Margin="3">Bottom Right</Button> <GridSplitter Grid.Row="1" Height="3" VerticalAlignment="Center" HorizontalAlignment="Stretch" ShowsPreview="False"></GridSplitter> </Grid> </Grid> </Window>