With the Opacity Mask
<Window xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation" xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml" x:Class="SDKSample.SampleViewer" Title="Examples" > <Canvas> <Image Height="150" Width="200" Source="c:\image.jpg" HorizontalAlignment="Left" Margin="10"> <Image.OpacityMask> <ImageBrush Viewport="0,0,50,50" ViewportUnits="Absolute" TileMode="Tile" ImageSource="c:\image.png"/> </Image.OpacityMask> </Image> </Canvas> </Window>