Use the setStyle() method to apply the custom class to the item renderer.

           

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    <!-- charts/CustomPlotRendererStyles.mxml -->
<s:Application xmlns:fx="http://ns.adobe.com/mxml/2009"
    xmlns:mx="library://ns.adobe.com/flex/mx" xmlns:s="library://ns.adobe.com/flex/spark"
    creationComplete="setStylesInit();" height="600">
  <fx:Script>
        import mx.core.BitmapAsset; 
    import mx.collections.ArrayCollection;
    [Bindable]
    public var expenses:ArrayCollection = new ArrayCollection([
      {month:"Jan", profit:20, expenses:15, amount:145},
      {month:"Feb", profit:1, expenses:2, amount:60},
      {month:"Mar", profit:15, expenses:5, amount:3}
      ]);

        [Bindable] 
        [Embed(source="a.jpg")] 
        public var myButterfly:Class; 
        private function setStylesInit():void { 
            series1.setStyle("itemRenderer", new ClassFactory(myButterfly)); 
            series1.setStyle("legendMarkerRenderer", new ClassFactory(myButterfly)); 
        } 
      </fx:Script>
    <s:layout>
        <s:VerticalLayout />
    </s:layout>
    <s:Panel title="Plot Chart">
        <s:layout>
            <s:VerticalLayout />
        </s:layout>
        <mx:PlotChart id="myChart" dataProvider="{expenses}"
            showDataTips="true">
            <mx:series>
                <!-- First series uses custom class renderer. -->
                <mx:PlotSeries id="series1" xField="expenses" yField="profit"
                    displayName="Plot 1" radius="20" />
                <!-- Second series uses CircleItemRenderer. -->
                <mx:PlotSeries id="series2" xField="amount" yField="expenses"
                    displayName="Plot 2" itemRenderer="mx.charts.renderers.CircleItemRenderer" />
                <!-- Third series uses CrossItemRenderer. -->
                <mx:PlotSeries id="series3" xField="profit" yField="amount"
                    displayName="Plot 3" itemRenderer="mx.charts.renderers.CrossItemRenderer" />
            </mx:series>
        </mx:PlotChart>
        <mx:Legend dataProvider="{myChart}" />
    </s:Panel>
</s:Application>

1.	Use setStyle() method, set it inline, or use Cascading Style Sheets (CSS)
2.	Using setStyle to programmatically manipulate a style property
3.	Use setStyle to change font size
4.	Use setStyle to change font style
5.	Cast target to a UIComponent before calling the setStyle() method
6.	Use setStyle() method
7.	Using the setStyle() method to apply graphical skins
8.	Using setStyle() method with a trigger
9.	Use getStyle() with effects defined in MXML
10.	Use getStyle() with behaviors defined in MXML
11.	Set a style property inline, and then reads that property with the getStyle() method

Use the setStyle() method to apply the custom class to the item renderer. : Style Get Set « Style « Flex

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