gov.nih.nci.rembrandt.web.xml.CopyNumberSampleReport.java Source code

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/*L
 * Copyright (c) 2006 SAIC, SAIC-F.
 *
 * Distributed under the OSI-approved BSD 3-Clause License.
 * See http://ncip.github.com/rembrandt/LICENSE.txt for details.
 */

package gov.nih.nci.rembrandt.web.xml;

import gov.nih.nci.caintegrator.dto.de.BioSpecimenIdentifierDE;
import gov.nih.nci.rembrandt.queryservice.resultset.DimensionalViewContainer;
import gov.nih.nci.rembrandt.queryservice.resultset.Resultant;
import gov.nih.nci.rembrandt.queryservice.resultset.ResultsContainer;
import gov.nih.nci.rembrandt.queryservice.resultset.copynumber.CopyNumberSingleViewResultsContainer;
import gov.nih.nci.rembrandt.queryservice.resultset.copynumber.CytobandResultset;
import gov.nih.nci.rembrandt.queryservice.resultset.copynumber.SampleCopyNumberValuesResultset;
import gov.nih.nci.rembrandt.queryservice.resultset.gene.ReporterResultset;
import gov.nih.nci.rembrandt.queryservice.resultset.gene.SampleFoldChangeValuesResultset;
import gov.nih.nci.rembrandt.queryservice.resultset.gene.ViewByGroupResultset;
import gov.nih.nci.rembrandt.util.ContextSensitiveHelpTag;
import gov.nih.nci.rembrandt.web.helper.FilterHelper;

import java.text.DecimalFormat;
import java.util.ArrayList;
import java.util.Collection;
import java.util.HashSet;
import java.util.Iterator;
import java.util.Map;

import org.apache.commons.lang.StringUtils;
import org.dom4j.Document;
import org.dom4j.DocumentHelper;
import org.dom4j.Element;

/**
 * @author LandyR
 * Feb 8, 2005
 * 
 */

/**
* caIntegrator License
* 
* Copyright 2001-2005 Science Applications International Corporation ("SAIC"). 
* The software subject to this notice and license includes both human readable source code form and machine readable, 
* binary, object code form ("the caIntegrator Software"). The caIntegrator Software was developed in conjunction with 
* the National Cancer Institute ("NCI") by NCI employees and employees of SAIC. 
* To the extent government employees are authors, any rights in such works shall be subject to Title 17 of the United States
* Code, section 105. 
* This caIntegrator Software License (the "License") is between NCI and You. "You (or "Your") shall mean a person or an 
* entity, and all other entities that control, are controlled by, or are under common control with the entity. "Control" 
* for purposes of this definition means (i) the direct or indirect power to cause the direction or management of such entity,
*  whether by contract or otherwise, or (ii) ownership of fifty percent (50%) or more of the outstanding shares, or (iii) 
* beneficial ownership of such entity. 
* This License is granted provided that You agree to the conditions described below. NCI grants You a non-exclusive, 
* worldwide, perpetual, fully-paid-up, no-charge, irrevocable, transferable and royalty-free right and license in its rights 
* in the caIntegrator Software to (i) use, install, access, operate, execute, copy, modify, translate, market, publicly 
* display, publicly perform, and prepare derivative works of the caIntegrator Software; (ii) distribute and have distributed 
* to and by third parties the caIntegrator Software and any modifications and derivative works thereof; 
* and (iii) sublicense the foregoing rights set out in (i) and (ii) to third parties, including the right to license such 
* rights to further third parties. For sake of clarity, and not by way of limitation, NCI shall have no right of accounting
* or right of payment from You or Your sublicensees for the rights granted under this License. This License is granted at no
* charge to You. 
* 1. Your redistributions of the source code for the Software must retain the above copyright notice, this list of conditions
*    and the disclaimer and limitation of liability of Article 6, below. Your redistributions in object code form must reproduce 
*    the above copyright notice, this list of conditions and the disclaimer of Article 6 in the documentation and/or other materials
*    provided with the distribution, if any. 
* 2. Your end-user documentation included with the redistribution, if any, must include the following acknowledgment: "This 
*    product includes software developed by SAIC and the National Cancer Institute." If You do not include such end-user 
*    documentation, You shall include this acknowledgment in the Software itself, wherever such third-party acknowledgments 
*    normally appear.
* 3. You may not use the names "The National Cancer Institute", "NCI" "Science Applications International Corporation" and 
*    "SAIC" to endorse or promote products derived from this Software. This License does not authorize You to use any 
*    trademarks, service marks, trade names, logos or product names of either NCI or SAIC, except as required to comply with
*    the terms of this License. 
* 4. For sake of clarity, and not by way of limitation, You may incorporate this Software into Your proprietary programs and 
*    into any third party proprietary programs. However, if You incorporate the Software into third party proprietary 
*    programs, You agree that You are solely responsible for obtaining any permission from such third parties required to 
*    incorporate the Software into such third party proprietary programs and for informing Your sublicensees, including 
*    without limitation Your end-users, of their obligation to secure any required permissions from such third parties 
*    before incorporating the Software into such third party proprietary software programs. In the event that You fail 
*    to obtain such permissions, You agree to indemnify NCI for any claims against NCI by such third parties, except to 
*    the extent prohibited by law, resulting from Your failure to obtain such permissions. 
* 5. For sake of clarity, and not by way of limitation, You may add Your own copyright statement to Your modifications and 
*    to the derivative works, and You may provide additional or different license terms and conditions in Your sublicenses 
*    of modifications of the Software, or any derivative works of the Software as a whole, provided Your use, reproduction, 
*    and distribution of the Work otherwise complies with the conditions stated in this License.
* 6. THIS SOFTWARE IS PROVIDED "AS IS," AND ANY EXPRESSED OR IMPLIED WARRANTIES, (INCLUDING, BUT NOT LIMITED TO, 
*    THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT AND FITNESS FOR A PARTICULAR PURPOSE) ARE DISCLAIMED. 
*    IN NO EVENT SHALL THE NATIONAL CANCER INSTITUTE, SAIC, OR THEIR AFFILIATES BE LIABLE FOR ANY DIRECT, INDIRECT, 
*    INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE 
*    GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF 
*    LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT 
*    OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
* 
*/

public class CopyNumberSampleReport implements ReportGenerator {

    /**
     * 
     */
    public CopyNumberSampleReport() {
        super();
    }

    /* (non-Javadoc)
     * @see gov.nih.nci.nautilus.ui.report.ReportGenerator#getTemplate(gov.nih.nci.nautilus.resultset.Resultant, java.lang.String)
     */
    public Document getReportXML(Resultant resultant, Map filterMapParams) {

        //String theColors[] = { "B6C5F2","F2E3B5","DAE1F9","C4F2B5","819BE9", "E9CF81" };
        DecimalFormat resultFormat = new DecimalFormat("0.0000");
        String delim = " | ";
        ArrayList filter_string = new ArrayList(); // hashmap of genes | reporters | cytobands
        String filter_type = "show"; // show | hide
        String filter_element = "none"; // none | gene | reporter | cytoband

        if (filterMapParams.containsKey("filter_string") && filterMapParams.get("filter_string") != null)
            filter_string = (ArrayList) filterMapParams.get("filter_string");
        if (filterMapParams.containsKey("filter_type") && filterMapParams.get("filter_type") != null)
            filter_type = (String) filterMapParams.get("filter_type");
        if (filterMapParams.containsKey("filter_element") && filterMapParams.get("filter_element") != null)
            filter_element = (String) filterMapParams.get("filter_element");

        Document document = DocumentHelper.createDocument();

        Element report = document.addElement("Report");
        Element cell = null;
        Element data = null;
        Element dataRow = null;
        //add the atts
        report.addAttribute("reportType", "Copy Number");
        report.addAttribute("helpLink", ContextSensitiveHelpTag.getHelpLink("Copy Number"));
        //fudge these for now
        report.addAttribute("groupBy", "none");
        String queryName = resultant.getAssociatedQuery().getQueryName();
        //set the queryName to be unique for session/cache access
        report.addAttribute("queryName", queryName);
        report.addAttribute("sessionId", "the session id");
        report.addAttribute("creationTime", "right now");
        //hold a message to display on the report
        report.addAttribute("msg", (resultant.isOverLimit() ? "over limit" : ""));

        StringBuffer sb = new StringBuffer();
        int recordCount = 0;
        int totalSamples = 0;

        ResultsContainer resultsContainer = resultant.getResultsContainer();

        CopyNumberSingleViewResultsContainer copyNumberContainer = null;

        if (resultsContainer instanceof DimensionalViewContainer) {
            DimensionalViewContainer dimensionalViewContainer = (DimensionalViewContainer) resultsContainer;
            if (dimensionalViewContainer != null) {
                copyNumberContainer = dimensionalViewContainer.getCopyNumberSingleViewContainer();
            }
        } else if (resultsContainer instanceof CopyNumberSingleViewResultsContainer) { //for single
            copyNumberContainer = (CopyNumberSingleViewResultsContainer) resultsContainer;
        }
        if (copyNumberContainer != null) {

            if (copyNumberContainer.getCytobandResultsets().size() > 0) {

                Collection cytobands = copyNumberContainer.getCytobandResultsets();
                Collection labels = copyNumberContainer.getGroupsLabels();
                Collection sampleIds = null;

                StringBuffer header = new StringBuffer();
                StringBuffer sampleNames = new StringBuffer();
                StringBuffer stringBuffer = new StringBuffer();

                /*
                sampleNames.append("<Tr>");
                sampleNames.append("<Td>&nbsp;</td><Td>&nbsp;</td>");
                    
                header.append("<tr>");
                header.append("<Td id=\"header\">Cytoband</td><td id=\"header\">Reporter</td>");
                */

                Element headerRow = report.addElement("Row").addAttribute("name", "headerRow");
                cell = headerRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "header")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText("Position");
                data = null;
                cell = null;
                cell = headerRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "header")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText("Genes");
                data = null;
                cell = null;
                cell = headerRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "header")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText("Segment ID");
                data = null;
                cell = null;

                /*
                 * Start annotations (csv only)
                 *  1) Bp position
                 *  2) associated genes (pipe delimimted list)
                 */
                cell = headerRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "csv")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText("Bp Position");
                data = null;
                cell = null;
                cell = headerRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "csv")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText("Genes");
                data = null;
                cell = null;

                Element sampleRow = report.addElement("Row").addAttribute("name", "sampleRow");
                cell = sampleRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "header")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText(" ");
                data = null;
                cell = null;
                cell = sampleRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "header")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText(" ");
                data = null;
                cell = null;
                cell = sampleRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "header")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText("z ");
                data = null;
                cell = null;

                cell = sampleRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "csv")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText(" ");
                data = null;
                cell = null;
                cell = sampleRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", "csv")
                        .addAttribute("group", "header");
                data = cell.addElement("Data").addAttribute("type", "header").addText(" ");
                data = null;
                cell = null;

                //this nested loop generates the header row and the samples row
                for (Iterator labelIterator = labels.iterator(); labelIterator.hasNext();) {
                    String label = (String) labelIterator.next();

                    sampleIds = copyNumberContainer.getBiospecimenLabels(label);
                    totalSamples += sampleIds.size();

                    cell = headerRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", label)
                            .addAttribute("group", label);
                    data = cell.addElement("Data").addAttribute("type", "header").addText(label + " Samples");
                    data = null;
                    cell = null;

                    //header.append("<Td colspan='"+sampleIds.size()+"' class=\""+label+"\" id=\"header\">"+label+" Samples</td>"); 

                    for (Iterator sampleIdIterator = sampleIds.iterator(); sampleIdIterator.hasNext();) {

                        BioSpecimenIdentifierDE bioSpecimenIdentifierDE = (BioSpecimenIdentifierDE) sampleIdIterator
                                .next();
                        cell = sampleRow.addElement("Cell").addAttribute("type", "header")
                                .addAttribute("class", label).addAttribute("group", label)
                                .addAttribute("sampleId", bioSpecimenIdentifierDE.getSampleId());
                        //cell = sampleRow.addElement("Cell").addAttribute("type", "header").addAttribute("class", label).addAttribute("group", label).addAttribute("specimen", bioSpecimenIdentifierDE.getSpecimenName());
                        //data = cell.addElement("Data").addAttribute("type", "header").addText(s.substring(2));
                        if (bioSpecimenIdentifierDE.getSpecimenName() != null) {
                            data = cell.addElement("Data").addAttribute("type", "header")
                                    .addText(bioSpecimenIdentifierDE.getSpecimenName());
                        } else {
                            data = cell.addElement("Data").addAttribute("type", "header")
                                    .addText(bioSpecimenIdentifierDE.getSampleId());
                        }
                        data = null;
                        cell = null;
                        //sampleNames.append("<td class='"+label+"' id=\"header\"><a href=\"report.do?s="+s+"&report=ss\">"+s.substring(2)+"</a></td>"); 
                        //theColspan += sampleIds.size();
                    }
                }
                //header.append("</tr>\n"); 
                //sampleNames.append("</tr>\n");

                /* done with the headerRow and SampleRow Elements, time to add data rows */

                for (Iterator cytobandIterator = cytobands.iterator(); cytobandIterator.hasNext();) {
                    CytobandResultset cytobandResultset = (CytobandResultset) cytobandIterator.next();
                    String cytoband = cytobandResultset.getCytoband().getValue().toString();
                    Collection reporters = copyNumberContainer.getRepoterResultsets(cytoband);

                    //         if(!filter_element.equals("cytoband") || (filter_element.equals("cytoband") && !filter_string.contains(cytoband)))   {
                    if (FilterHelper.checkFilter(filter_element, "cytoband", cytoband, filter_type,
                            filter_string)) {

                        recordCount += reporters.size();
                        for (Iterator reporterIterator = reporters.iterator(); reporterIterator.hasNext();) {

                            ReporterResultset reporterResultset = (ReporterResultset) reporterIterator.next();

                            /*
                             * 
                             *  store our annotations
                             * 
                             */
                            String bp_position = "";
                            try {
                                bp_position = reporterResultset.getStartPhysicalLocation().getValue().toString();
                            } catch (Exception e) {
                            }

                            //there is a much better way to do this, but this is reused from 0.50
                            //this code will be cleaned up for 1.0
                            String genes = "";
                            try {
                                if (reporterResultset.getAssiciatedGeneSymbols() != null) {
                                    HashSet geneSymbols = new HashSet(reporterResultset.getAssiciatedGeneSymbols());
                                    genes = StringUtils.join(geneSymbols.toArray(), delim);

                                } else {
                                    genes = "-";
                                }
                            } catch (Exception e) {
                                genes = "--";
                            }

                            String reporterName = reporterResultset.getReporter().getValue().toString();

                            if (FilterHelper.checkFilter(filter_element, "reporter", reporterName, filter_type,
                                    filter_string)) {
                                //if(!filter_element.equals("reporter") || (filter_element.equals("reporter") && !filter_string.contains(reporterName)))   {      
                                dataRow = report.addElement("Row").addAttribute("name", "dataRow");
                                cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                        .addAttribute("class", "cytoband").addAttribute("group", "header");
                                data = cell.addElement("Data").addAttribute("type", "header").addText(cytoband);
                                data = null;
                                cell = null;

                                cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                        .addAttribute("class", "gene").addAttribute("group", "header");
                                data = cell.addElement("Data").addAttribute("type", "header").addText(genes);
                                data = null;
                                cell = null;

                                cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                        .addAttribute("class", "reporter").addAttribute("group", "header");
                                data = cell.addElement("Data").addAttribute("type", "header").addText(reporterName);
                                data = null;
                                cell = null;
                                //sb.append("<tr><td>"+cytoband+"</td><td>"+reporterName+"</td>");

                                /*
                                 * 
                                 *  actually add the annotations to the report
                                 * 
                                 */
                                cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                        .addAttribute("class", "csv").addAttribute("group", "header");
                                data = cell.addElement("Data").addAttribute("type", "header").addText(bp_position);
                                data = null;
                                cell = null;
                                cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                        .addAttribute("class", "csv").addAttribute("group", "header");
                                data = cell.addElement("Data").addAttribute("type", "header").addText(genes);
                                data = null;
                                cell = null;

                                for (Iterator labelIterator = labels.iterator(); labelIterator.hasNext();) {
                                    String label = (String) labelIterator.next();
                                    ViewByGroupResultset groupResultset = (ViewByGroupResultset) reporterResultset
                                            .getGroupByResultset(label);

                                    sampleIds = copyNumberContainer.getBiospecimenLabels(label);
                                    String hClass = label;
                                    if (groupResultset != null) {
                                        for (Iterator sampleIdIterator = sampleIds.iterator(); sampleIdIterator
                                                .hasNext();) {

                                            BioSpecimenIdentifierDE sampleId = (BioSpecimenIdentifierDE) sampleIdIterator
                                                    .next();
                                            SampleCopyNumberValuesResultset sampleResultset2 = (SampleCopyNumberValuesResultset) groupResultset
                                                    .getBioSpecimenResultset(sampleId.getSpecimenName());

                                            if (sampleResultset2 != null) {

                                                //JB Begin: Add for GForge # 17783 - Advance Query Reports - Make the report more user friendly (Provide tool tip)
                                                String tooltip = "Position = " + cytoband + ", Gene = " + genes
                                                        + ", Reporter = " + reporterName + ", Sample = "
                                                        + sampleId.getSampleId() + " (" + sampleId.getSpecimenName()
                                                        + ")";
                                                //JB End: Add for GForge # 17783 - Advance Query Reports - Make the report more user friendly (Provide tool tip)

                                                if (sampleResultset2.isHighlighted())
                                                    hClass = "highlighted";
                                                else
                                                    hClass = label;

                                                Double ratio = (Double) sampleResultset2.getCopyNumber().getValue();
                                                Double segMean = (Double) sampleResultset2.getSegmentMean()
                                                        .getValue();
                                                if (ratio != null && segMean != null) {
                                                    //sb.append("<td class='"+label+"'>"+resultFormat.format(ratio)+"</td>");
                                                    cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                                            .addAttribute("class", hClass)
                                                            .addAttribute("group", label);
                                                    //JB Begin: Add for GForge # 17783 - Advance Query Reports - Make the report more user friendly (Provide tool tip)
                                                    //data = cell.addElement("Data").addAttribute("type", "data").addText(resultFormat.format(ratio));
                                                    data = cell.addElement("Data").addAttribute("type", "data")
                                                            .addAttribute("datainfo", tooltip)
                                                            .addText(resultFormat.format(ratio) + "("
                                                                    + resultFormat.format(segMean) + ")");
                                                    //JB End: Add for GForge # 17783 - Advance Query Reports - Make the report more user friendly (Provide tool tip)
                                                    data = null;
                                                    cell = null;
                                                } else {
                                                    //sb.append("<td class='"+label+"'>-</td>");
                                                    cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                                            .addAttribute("class", hClass)
                                                            .addAttribute("group", label);
                                                    data = cell.addElement("Data").addAttribute("type", "data")
                                                            .addText("-");
                                                    data = null;
                                                    cell = null;
                                                }
                                            } else {
                                                //sb.append("<td class='"+label+"'>-</td>");

                                                cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                                        .addAttribute("class", hClass).addAttribute("group", label);
                                                data = cell.addElement("Data").addAttribute("type", "data")
                                                        .addText("-");
                                                data = null;
                                                cell = null;
                                            }
                                        }
                                    } else {
                                        for (int s = 0; s < sampleIds.size(); s++) {
                                            cell = dataRow.addElement("Cell").addAttribute("type", "data")
                                                    .addAttribute("class", hClass).addAttribute("group", label);
                                            data = cell.addElement("Data").addAttribute("type", "data")
                                                    .addText("-");
                                            data = null;
                                            cell = null;
                                            //sb.append("<td class='"+label+"'>-</td>");
                                        }
                                    }
                                }
                                //sb.append("</tr>\n");
                            } /* close reporter filter */
                        }
                        //sb.append("<tr><td colspan=\""+theColspan+"\" class=\"geneSpacerStyle\">&nbsp;</td></tr>\n");
                    } /* close cyto filter */
                    //sb.append("</table><Br><br>");
                }
            }

            else {
                //TODO: handle these errs
                sb.append("<br><br>Copy Number container is empty");
            }

        } else {
            //TODO: handle these errs
            sb.append("<br><br>Copy Number container is empty");
        }

        return document;
        //return "<div class=\"rowCount\">"+ helpFul +recordCount+" records returned. "+ totalSamples + " samples returned. &nbsp;&nbsp;&nbsp;" + links +"</div>\n" + sb.toString();
    }

}