ffx.xray.CNSFilter.java Source code

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/**
 * Title: Force Field X.
 *
 * Description: Force Field X - Software for Molecular Biophysics.
 *
 * Copyright: Copyright (c) Michael J. Schnieders 2001-2015.
 *
 * This file is part of Force Field X.
 *
 * Force Field X is free software; you can redistribute it and/or modify it
 * under the terms of the GNU General Public License version 3 as published by
 * the Free Software Foundation.
 *
 * Force Field X is distributed in the hope that it will be useful, but WITHOUT
 * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
 * FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
 * details.
 *
 * You should have received a copy of the GNU General Public License along with
 * Force Field X; if not, write to the Free Software Foundation, Inc., 59 Temple
 * Place, Suite 330, Boston, MA 02111-1307 USA
 *
 * Linking this library statically or dynamically with other modules is making a
 * combined work based on this library. Thus, the terms and conditions of the
 * GNU General Public License cover the whole combination.
 *
 * As a special exception, the copyright holders of this library give you
 * permission to link this library with independent modules to produce an
 * executable, regardless of the license terms of these independent modules, and
 * to copy and distribute the resulting executable under terms of your choice,
 * provided that you also meet, for each linked independent module, the terms
 * and conditions of the license of that module. An independent module is a
 * module which is not derived from or based on this library. If you modify this
 * library, you may extend this exception to your version of the library, but
 * you are not obligated to do so. If you do not wish to do so, delete this
 * exception statement from your version.
 */
package ffx.xray;

import java.io.BufferedReader;
import java.io.File;
import java.io.FileReader;
import java.io.IOException;
import java.util.logging.Level;
import java.util.logging.Logger;

import org.apache.commons.configuration.CompositeConfiguration;

import ffx.crystal.Crystal;
import ffx.crystal.HKL;
import ffx.crystal.ReflectionList;
import ffx.crystal.Resolution;
import ffx.crystal.SpaceGroup;

/**
 * <p>
 * CNSFilter class.</p>
 *
 * @author Timothy D. Fenn
 *
 */
public class CNSFilter implements DiffractionFileFilter {

    private static final Logger logger = Logger.getLogger(CNSFilter.class.getName());
    private double cell[] = { -1.0, -1.0, -1.0, -1.0, -1.0, -1.0 };
    private double reshigh = -1.0;
    private String fostring, sigfostring, rfreestring;
    private String sgname = null;
    private int sgnum = -1;

    // null constructor
    /**
     * <p>
     * Constructor for CNSFilter.</p>
     */
    public CNSFilter() {
    }

    /**
     * {@inheritDoc}
     */
    @Override
    public ReflectionList getReflectionList(File cnsFile) {
        return getReflectionList(cnsFile, null);
    }

    /**
     * {@inheritDoc}
     */
    @Override
    public ReflectionList getReflectionList(File cnsFile, CompositeConfiguration properties) {
        try {
            BufferedReader br = new BufferedReader(new FileReader(cnsFile));

            String str;
            while ((str = br.readLine()) != null) {
                String strarray[] = str.split("\\s+");

                if (strarray[0].equalsIgnoreCase("{")) {
                    if (strarray[1].toLowerCase().startsWith("sg=")) {
                        sgname = strarray[1].substring(3);
                        cell[0] = Double.parseDouble(strarray[2].substring(2));
                        cell[1] = Double.parseDouble(strarray[3].substring(2));
                        cell[2] = Double.parseDouble(strarray[4].substring(2));
                        cell[3] = Double.parseDouble(strarray[5].substring(6));
                        cell[4] = Double.parseDouble(strarray[6].substring(5));
                        cell[5] = Double.parseDouble(strarray[7].substring(6));
                    }
                } else if (strarray[0].equalsIgnoreCase("CRYST1")) {
                    cell[0] = Double.parseDouble(strarray[1]);
                    cell[1] = Double.parseDouble(strarray[2]);
                    cell[2] = Double.parseDouble(strarray[3]);
                    cell[3] = Double.parseDouble(strarray[4]);
                    cell[4] = Double.parseDouble(strarray[5]);
                    cell[5] = Double.parseDouble(strarray[6]);
                    sgname = SpaceGroup.pdb2ShortName(str.substring(55, 65));
                } else if (strarray[0].toLowerCase().startsWith("inde")) {
                    break;
                }
            }

            br.close();
        } catch (IOException ioe) {
            System.out.println("IO Exception: " + ioe.getMessage());
            return null;
        }

        Resolution resolution = null;
        if (properties != null) {
            resolution = Resolution.checkProperties(properties);
            reshigh = resolution.resolution;
        }

        if (sgname != null) {
            sgnum = SpaceGroup.spaceGroupNumber(sgname);
        }

        if (sgnum < 0 || cell[0] < 0 || resolution == null) {
            logger.info(" The CNS file contains insufficient information to generate the reflection list.");
            return null;
        }

        if (logger.isLoggable(Level.INFO)) {
            StringBuilder sb = new StringBuilder();
            sb.append(String.format("\nOpening %s\n", cnsFile.getName()));
            sb.append(String.format("setting up Reflection List based on CNS:\n"));
            sb.append(
                    String.format("  spacegroup #: %d (name: %s)\n", sgnum, SpaceGroup.spaceGroupNames[sgnum - 1]));
            sb.append(String.format("  resolution: %8.3f\n", reshigh));
            sb.append(String.format("  cell: %8.3f %8.3f %8.3f %8.3f %8.3f %8.3f\n", cell[0], cell[1], cell[2],
                    cell[3], cell[4], cell[5]));
            logger.info(sb.toString());
        }

        Crystal crystal = new Crystal(cell[0], cell[1], cell[2], cell[3], cell[4], cell[5],
                SpaceGroup.spaceGroupNames[sgnum - 1]);

        ReflectionList reflectionlist = new ReflectionList(crystal, resolution, properties);
        return reflectionlist;
    }

    /**
     * {@inheritDoc}
     */
    @Override
    public double getResolution(File cnsFile, Crystal crystal) {
        double res = Double.POSITIVE_INFINITY;

        try {
            BufferedReader br = new BufferedReader(new FileReader(cnsFile));

            String str;
            boolean hashkl, hasfo, hassigfo, hasfree;
            int ih, ik, il;
            HKL hkl = new HKL();

            ih = ik = il = -1;

            while ((str = br.readLine()) != null) {
                String strarray[] = str.split("\\s+");

                for (int i = 0; i < strarray.length; i++) {
                    if (strarray[i].toLowerCase().startsWith("inde")) {
                        if (i < strarray.length - 3) {
                            ih = Integer.parseInt(strarray[i + 1]);
                            ik = Integer.parseInt(strarray[i + 2]);
                            il = Integer.parseInt(strarray[i + 3]);
                            hkl.h(ih);
                            hkl.k(ik);
                            hkl.l(il);
                            res = Math.min(res, Crystal.res(crystal, hkl));
                        }
                    }
                }
            }
        } catch (IOException ioe) {
            System.out.println("IO Exception: " + ioe.getMessage());
            return -1.0;
        }

        return res;
    }

    /**
     * {@inheritDoc}
     */
    @Override
    public boolean readFile(File cnsFile, ReflectionList reflectionlist, DiffractionRefinementData refinementdata,
            CompositeConfiguration properties) {
        int nread, nres, nignore, nfriedel, ncut;
        boolean transpose = false;

        StringBuilder sb = new StringBuilder();
        sb.append(String.format("\n Opening %s\n", cnsFile.getName()));
        if (refinementdata.rfreeflag < 0) {
            refinementdata.setFreeRFlag(1);
            sb.append(String.format(" Setting R free flag to CNS default: %d\n", refinementdata.rfreeflag));
        }

        try {
            BufferedReader br = new BufferedReader(new FileReader(cnsFile));

            String str;
            boolean hashkl, hasfo, hassigfo, hasfree;
            int ih, ik, il, free;
            double fo, sigfo;

            hashkl = hasfo = hassigfo = hasfree = false;
            ih = ik = il = free = -1;
            fo = sigfo = -1.0;

            // check if HKLs need to be transposed or not
            HKL mate = new HKL();
            int nposignore = 0;
            int ntransignore = 0;
            while ((str = br.readLine()) != null) {
                String strarray[] = str.split("\\s+");

                for (int i = 0; i < strarray.length; i++) {
                    if (strarray[i].toLowerCase().startsWith("inde")) {
                        if (i < strarray.length - 3) {
                            ih = Integer.parseInt(strarray[i + 1]);
                            ik = Integer.parseInt(strarray[i + 2]);
                            il = Integer.parseInt(strarray[i + 3]);
                            boolean friedel = reflectionlist.findSymHKL(ih, ik, il, mate, false);
                            HKL hklpos = reflectionlist.getHKL(mate);
                            if (hklpos == null) {
                                nposignore++;
                            }

                            friedel = reflectionlist.findSymHKL(ih, ik, il, mate, true);
                            HKL hkltrans = reflectionlist.getHKL(mate);
                            if (hkltrans == null) {
                                ntransignore++;
                            }
                        }
                    }
                }
            }
            if (nposignore > ntransignore) {
                transpose = true;
            }

            // column identifiers
            fostring = sigfostring = rfreestring = null;
            if (properties != null) {
                fostring = properties.getString("fostring", null);
                sigfostring = properties.getString("sigfostring", null);
                rfreestring = properties.getString("rfreestring", null);
            }

            // reopen to start at beginning
            br = new BufferedReader(new FileReader(cnsFile));

            // read in data
            double anofsigf[][] = new double[refinementdata.n][4];
            for (int i = 0; i < refinementdata.n; i++) {
                anofsigf[i][0] = anofsigf[i][1] = anofsigf[i][2] = anofsigf[i][3] = Double.NaN;
            }
            nread = nres = nignore = nfriedel = ncut = 0;
            while ((str = br.readLine()) != null) {
                String strarray[] = str.split("\\s+");

                for (int i = 0; i < strarray.length; i++) {
                    if (strarray[i].toLowerCase().startsWith("inde")) {
                        if (hashkl && hasfo && hassigfo && hasfree) {
                            boolean friedel = reflectionlist.findSymHKL(ih, ik, il, mate, transpose);
                            HKL hkl = reflectionlist.getHKL(mate);
                            if (hkl != null) {
                                if (refinementdata.fsigfcutoff > 0.0 && (fo / sigfo) < refinementdata.fsigfcutoff) {
                                    ncut++;
                                } else if (friedel) {
                                    anofsigf[hkl.index()][2] = fo;
                                    anofsigf[hkl.index()][3] = sigfo;
                                    nfriedel++;
                                } else if (!friedel) {
                                    anofsigf[hkl.index()][0] = fo;
                                    anofsigf[hkl.index()][1] = sigfo;
                                }
                                refinementdata.setFreeR(hkl.index(), free);
                                nread++;
                            } else {
                                HKL tmp = new HKL(ih, ik, il);
                                if (!reflectionlist.resolution
                                        .inInverseResSqRange(Crystal.invressq(reflectionlist.crystal, tmp))) {
                                    nres++;
                                } else {
                                    nignore++;
                                }
                            }
                        }
                        hashkl = false;
                        hasfo = false;
                        hassigfo = false;
                        hasfree = false;
                        if (i < strarray.length - 3) {
                            ih = Integer.parseInt(strarray[i + 1]);
                            ik = Integer.parseInt(strarray[i + 2]);
                            il = Integer.parseInt(strarray[i + 3]);
                            hashkl = true;
                        }
                    }
                    if (strarray[i].toLowerCase().startsWith("fobs=")
                            || strarray[i].equalsIgnoreCase(fostring + "=")) {
                        fo = Double.parseDouble(strarray[i + 1]);
                        hasfo = true;
                    }
                    if (strarray[i].toLowerCase().startsWith("sigma=")
                            || strarray[i].equalsIgnoreCase(sigfostring + "=")) {
                        sigfo = Double.parseDouble(strarray[i + 1]);
                        hassigfo = true;
                    }
                    if (strarray[i].toLowerCase().startsWith("test=")
                            || strarray[i].equalsIgnoreCase(rfreestring + "=")) {
                        free = Integer.parseInt(strarray[i + 1]);
                        hasfree = true;
                    }
                }
            }

            br.close();

            // set up fsigf from F+ and F-
            refinementdata.generate_fsigf_from_anofsigf(anofsigf);
        } catch (IOException ioe) {
            System.out.println("IO Exception: " + ioe.getMessage());
            return false;
        }

        sb.append(String.format("# HKL read in:                             %d\n", nread));
        sb.append(String.format("# HKL read as friedel mates:               %d\n", nfriedel));
        sb.append(String.format("# HKL NOT read in (too high resolution):   %d\n", nres));
        sb.append(String.format("# HKL NOT read in (not in internal list?): %d\n", nignore));
        sb.append(String.format("# HKL NOT read in (F/sigF cutoff):         %d\n", ncut));
        sb.append(String.format("# HKL in internal list:                    %d\n", reflectionlist.hkllist.size()));
        if (logger.isLoggable(Level.INFO)) {
            logger.info(sb.toString());
        }

        return true;
    }
}