mysql>
mysql> SELECT TIMEDIFF('2000:01:01 00:00:00', '2000:01:01 00:00:00.000001');
+---------------------------------------------------------------+
| TIMEDIFF('2000:01:01 00:00:00', '2000:01:01 00:00:00.000001') |
+---------------------------------------------------------------+
| -00:00:00.000001 |
+---------------------------------------------------------------+
1 row in set (0.01 sec)