They can be manipulated using numeric operations.
mysql>
mysql> CREATE Table Test(
-> Advertiser SET('A','B','C')
-> );
Query OK, 0 rows affected (0.03 sec)
mysql>
mysql>
mysql> INSERT INTO Test (Advertiser) values('A, B');
Query OK, 1 row affected, 1 warning (0.00 sec)
mysql>
mysql>
mysql> SELECT * FROM Test WHERE Advertiser = 1;
+------------+
| Advertiser |
+------------+
| A |
+------------+
1 row in set (0.02 sec)
mysql>
mysql> SELECT Advertiser, Advertiser + 0 FROM Test;
+------------+----------------+
| Advertiser | Advertiser + 0 |
+------------+----------------+
| A | 1 |
+------------+----------------+
1 row in set (0.00 sec)
mysql>
mysql> drop table Test;
Query OK, 0 rows affected (0.00 sec)
mysql>