You can create a dependency between a cached page and a file (or set of files) on your hard drive.
When the file is modified, the cached page is automatically dropped and regenerated with the next page request.
<%@ Page Language="C#" %>
<%@ OutputCache Duration="9999" VaryByParam="none" %>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
"http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<script runat="server">
void Page_Load()
{
Response.AddFileDependency(MapPath("Data.xml"));
}
</script>
<html xmlns="http://www.w3.org/1999/xhtml" >
<head id="Head1" runat="server">
<title>Output Cache File Dependency</title>
</head>
<body>
<form id="form1" runat="server">
<div>
<%= DateTime.Now.ToString("T") %>
<hr />
<asp:GridView
id="grdProducts"
DataSourceID="srcProducts"
Runat="server" />
<asp:XmlDataSource
id="srcProducts"
DataFile="Data.xml"
Runat="server" />
</div>
</form>
</body>
</html>