Set the padding to 10 pixels, and the gap to 5 pixels, for the children of a Panel container:

            

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<!-- containers\spark\SparkPanelPadding.mxml -->
<s:Application xmlns:fx="http://ns.adobe.com/mxml/2009"
    xmlns:mx="library://ns.adobe.com/flex/mx"
    xmlns:s="library://ns.adobe.com/flex/spark">
    <s:Panel>
        <s:layout>
            <s:HorizontalLayout paddingLeft="10" paddingRight="10"
                paddingTop="10" paddingBottom="10" gap="5" />
        </s:layout>
        <s:Button label="Button 1" />
        <s:Button label="Button 2" />
        <s:Button label="Button 3" />
        <s:Button label="Button 4" />
    </s:Panel>
</s:Application>

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Set the padding to 10 pixels, and the gap to 5 pixels, for the children of a Panel container: : Panel Children « Container « Flex

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