Map some HRules and VRules to constraint rows and columns
<mx:Application xmlns:mx="http://www.adobe.com/2006/mxml" layout="absolute">
<mx:constraintColumns>
<mx:ConstraintColumn id="col1" width="200" />
<mx:ConstraintColumn id="col2" width="100%" />
</mx:constraintColumns>
<mx:constraintRows>
<mx:ConstraintRow id="row1" height="100" />
<mx:ConstraintRow id="row2" height="100%" />
</mx:constraintRows>
<mx:VRule height="100%" left="col1:0" />
<mx:VRule height="100%" left="col2:0" />
<mx:HRule width="100%" top="row1:0" />
<mx:HRule width="100%" top="row2:0" />
<mx:Button label="column 1, row 1" left="col1:5" right="col1:5" top="row1:5" bottom="row1:5" />
<mx:Button label="column 1, row 2" left="col1:5" right="col1:5" top="row2:5" bottom="row2:5" />
<mx:Button label="column 2, row 1" left="col2:5" right="col2:5" top="row1:5" bottom="row1:5" />
<mx:Button label="column 2, row 2" left="col2:5" right="col2:5" top="row2:5" bottom="row2:5" />
</mx:Application>
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