AppDomain.Unload
using System; using System.Runtime.Remoting; using System.Reflection; class MainClass { public static void Main() { AppDomain d = AppDomain.CreateDomain("NewDomain"); ObjectHandle hobj = d.CreateInstance("AnotherDomain", "SimpleObject"); SimpleObject so = (SimpleObject) hobj.Unwrap(); Console.WriteLine(so.Display("make this uppercase")); AppDomain.Unload(d); Console.WriteLine(so.Display("make this uppercase")); } } [Serializable] public class SimpleObject { public String Display(String inString) { return(inString.ToUpper()); } }