AppDomain.CreateDomain
using System; class MainClass { public static void Main() { AppDomainSetup setupInfo = new AppDomainSetup(); setupInfo.ApplicationBase = @"C:\MyRootDirectory"; setupInfo.ConfigurationFile = "MyApp.config"; setupInfo.PrivateBinPath = "bin;plugins;external"; AppDomain newDomain = AppDomain.CreateDomain("My New AppDomain", null, setupInfo); } }